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Category:2010 software
Category:Building information modelling
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Category:Aircraft simulatorsSilibinin, an inhibitor of microsomal prostaglandin synthetase, suppresses prostaglandin E2 and leukotriene B4 synthesis induced by antigen-antibody reaction in guinea pig peritoneal exudate cells.
Silibinin, an extract from the seeds of milk thistle (Silybum marianum), is known as a potent inhibitor of cytochrome P450 system. In the present study, the effects of silibinin on antigen-antibody reaction, which was assumed to be induced by release of prostaglandins (PGs) and leukotrienes (LTs), were investigated using a peritoneal exudate cell assay. Silibinin, at concentrations of 1 microM and higher, suppressed PGE2 and LTB4 synthesis in antigen-antibody-induced cells in a dose-dependent fashion. In contrast, the suppressive effect on 13-cis-retinoic acid formation induced by antigen-antibody reaction was not observed even at the concentration of 100 microM. In addition, cyclooxygenase activity, as assessed by arachidonic acid-induced PGE2 formation, and leukotriene-synthe ting activity, as assessed by [3H]LTC4 synthesis, were also inhibited in the antigen-antibody reaction. In conclusion, the present results suggest that silibinin has an inhibitory effect on biosynthesis of PGs and LTs in antigen-antibody-induced cells, probably through inhibition of cyclooxygenase activity and/or LT-synthetizing activity.—
id: version-0.16-navigation
title: Navigation
sidebar_label: Navigation
original_id: navigation

Controls and lists that contain multiple sibling content items can group the items into a navigation. This is useful if you want to tell the user where they are in the app, and where they can go next.
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